Mixed steatohepatitis: more questions than answers (part 2)

被引：0

作者：

Raikhelson, Karina L. ^{[1
]}

Kondrashina, Elina A. ^{[1
]}

Pazenko, Ekaterina, V ^{[1
]}

机构：

[1] St Petersburg State Univ, St Petersburg, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2021年 / 93卷 / 04期

关键词：

steatohepatitis; non-alcoholic fatty liver disease; metabolic associated fatty liver disease; drug-induced liver injury; ademetionine; INDUCED LIVER-INJURY; ACG CLINICAL GUIDELINE; NONALCOHOLIC STEATOHEPATITIS; S-ADENOSYLMETHIONINE; RISK-FACTORS; MITOCHONDRIAL DYSFUNCTION; METHOTREXATE; DISEASE; TAMOXIFEN; FIBROSIS;

D O I：

10.26442/00403660.2021.04.200755

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, we discussed the epidemiological and pathogenetic aspects of mixed steatohepatitis (SH), developed due to non-alcoholic fatty liver disease, metabolic associated fatty liver disease, drug-induced liver injury. We discussed the mechanisms of the mutually aggravating influence of etiological factors. Drugs can cause steatosis and SH, as well as contribute to the progressive course of existing SH, primarily of metabolic origin. The issues of interaction of pathogenetic factors, peculiarities of diagnostics and perspectives of pathogenetic and symptomatic treatment are considered. Therapy of mixed SH is based on avoidance of hepatotoxic drugs and lifestyle modification, medications with demonstrated efficacy (such as ademetionine) in certain SH might be used.

引用

页码：516 / 520

页数：5

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