Exosomes in cancer development and clinical applications

被引：356

作者：

Tai, Yu-Ling ^{[1
,2
,3
]}

Chen, Ko-Chien ^{[1
,2
]}

Hsieh, Jer-Tsong ^{[3
,4
]}

Shen, Tang-Long ^{[1
,2
,4
]}

机构：

[1] Natl Taiwan Univ, Dept Plant Pathol & Microbiol, Taipei, Taiwan

[2] Natl Taiwan Univ, Ctr Biotechnol, Taipei, Taiwan

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA

[4] Chinese Med Univ, Inst Biomed Sci, Taichung, Taiwan

来源：

CANCER SCIENCE | 2018年 / 109卷 / 08期

关键词：

biomarker; cancer malignancy; cancer therapy; drug resistance; exosome; PROMOTE TUMOR-GROWTH; EXTRACELLULAR VESICLES; PROSTATE-CANCER; CELL; MICROVESICLES; RNA; RESISTANCE; THERAPY; RELEASE; MICROENVIRONMENT;

D O I：

10.1111/cas.13697

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes participate in cancer progression and metastasis by transferring bioactive molecules between cancer and various cells in the local and distant microenvironments. Such intercellular cross-talk results in changes in multiple cellular and biological functions in recipient cells. Several hallmarks of cancer have reportedly been impacted by this exosome-mediated cell-to-cell communication, including modulating immune responses, reprogramming stromal cells, remodeling the architecture of the extracellular matrix, or even endowing cancer cells with characteristics of drug resistance. Selectively, loading specific oncogenic molecules into exosomes highlights exosomes as potential diagnostic biomarkers as well as therapeutic targets. In addition, exosome-based drug delivery strategies in preclinical and clinical trials have been shown to dramatically decrease cancer development. In the present review, we summarize the significant aspects of exosomes in cancer development that can provide novel strategies for potential clinical applications.

引用

页码：2364 / 2374

页数：11

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