ASSOCIATION BETWEEN PORPHYRIA CUTANEA TARDA AND BETA-THALASSEMIA MAJOR

被引：1

作者：

Barbieri, L. ^{[1
]}

Macri, A. ^{[1
]}

Palmieri, G. Lupia ^{[1
]}

Aurizi, C. ^{[1
]}

Biolcati, G. ^{[1
]}

机构：

[1] IRCCS, Ist San Gallicano, Struttura Semplice Dipartimentale, Ctr Porfirie & Malattie Metab Ereditarie, I-00144 Rome, Italy

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2009年 / 55卷 / 02期

关键词：

Porphyria Cutanea Tarda; beta-thalassemia; Hepatitis C virus infection; Iron overload; Chloroquine; C VIRUS-INFECTION; UROPORPHYRINOGEN DECARBOXYLASE; CHLOROQUINE; LIVER;

D O I：

10.1170/T850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paper describes the first two cases of porphyria cutanea tarda associated with beta-thalassemia major. The clinical course of two female patients affected by beta-thalassemia major was complicated by the onset of porphyria cutanea tarda. Both patients were also suffering from hepatitis C virus infection, iron overload and anemia. We discuss about the role performed by some of these conditions in triggering overt porphyria cutanea tarda. An improvement of the clinical and biochemical picture of porphyria cutanea tarda in both patients was obtained with chloroquine therapy given that their chronic anemia did not permit phlebotomy.

引用

页码：36 / 39

页数：4

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