Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments

被引：99

作者：

Maeda, Kazuhiro ^{[1
]}

Yoshida, Ken ^{[2
]}

Nishizawa, Tetsuro ^{[1
]}

Otani, Kazuhiro ^{[2
]}

Yamashita, Yu ^{[1
]}

Okabe, Hinako ^{[1
]}

Hadano, Yuka ^{[1
]}

Kayama, Tomohiro ^{[1
]}

Kurosaka, Daitaro ^{[2
]}

Saito, Mitsuru ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Dept Orthopaed Surg, Minato Ku, 3-25-8 Nishi Shimbashi, Tokyo 1058461, Japan

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Rheumatol,Minato Ku, 3-25-8 Nishi Shimbashi, Tokyo 1058461, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 05期

关键词：

rheumatoid arthritis; osteoporosis; osteoclast; fibroblast; RANKL; DKK-1; TNF-alpha; IL-6; CTLA-4; JAK; COLLAGEN-INDUCED ARTHRITIS; NECROSIS-FACTOR RECEPTOR; LONG-TERM TREATMENT; MINERAL DENSITY; PARATHYROID-HORMONE; BETA-CATENIN; SERUM-LEVELS; TNF-ALPHA; B-CELLS; PRECLINICAL CHARACTERIZATION;

D O I：

10.3390/ijms23052871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms and pathologies often presenting with polyarthritis. The primary symptom in the initial stage is joint swelling due to synovitis. With disease progression, cartilage and bone are affected to cause joint deformities. Advanced osteoarticular destruction and deformation can cause irreversible physical disabilities. Physical disabilities not only deteriorate patients' quality of life but also have substantial medical economic effects on society. Therefore, prevention of the progression of osteoarticular destruction and deformation is an important task. Recent studies have progressively improved our understanding of the molecular mechanism by which synovitis caused by immune disorders results in activation of osteoclasts; activated osteoclasts in turn cause bone destruction and para-articular osteoporosis. In this paper, we review the mechanisms of bone metabolism under physiological and RA conditions, and we describe the effects of therapeutic intervention against RA on bone.

引用

页数：24

共 208 条

[1]

Abu-Shakra M, 2018, ISR MED ASSOC J, V20, P239

[2] JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function [J].