Plasmonic nanosensors for imaging intracellular biomarkers in live cells

被引：186

作者：

Kumar, Sonia

Harrison, Nathan

Richards-Kortum, Rebecca

Sokolov, Konstantin ^{[1
]}

机构：

[1] Univ Texas, Dept Biomed Engn, Austin, TX 78712 USA

[2] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Biol Engn, Houston, TX 77030 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 05期

关键词：

D O I：

10.1021/nl070365i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we present the first intracellular molecular imaging platform using multifunctional gold nanoparticles which incorporate both cytosolic delivery and targeting moieties on the same particle. The utility of these intracellular sensors was demonstrated by monitoring actin rearrangement in live fibroblasts. We observed a strong molecular specific optical signal associated with effective targeting of actin filaments. These multifunctional nanosensors can be adapted to target various intracellular processes especially where transfection or cytotoxic labels are not feasible.

引用

页码：1338 / 1343

页数：6

共 29 条

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