Linking DNA Damage, NAD+/SIRT1, and Aging

被引：31
作者：
Guarente, Leonard [1 ,2 ]
机构：
[1] MIT, Glenn Labs Sci Aging, Cambridge, MA 02139 USA
[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
来源：
CELL METABOLISM | 2014年 / 20卷 / 05期
关键词：
HISTONE DEACETYLASE; LONGEVITY; MICE;
D O I：
10.1016/j.cmet.2014.10.015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD + levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD + depletion by the DNA repair protein PARP.
引用
收藏
页码：706 / 707
页数：2
相关论文
共 10 条
  • [1] The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
    Canto, Caries
    Houtkooper, Riekelt H.
    Pirinen, Eija
    Youn, Dou Y.
    Oosterveer, Maaike H.
    Cen, Yana
    Fernandez-Marcos, Pablo J.
    Yamamoto, Hiroyasu
    Andreux, Penelope A.
    Cettour-Rose, Philippe
    Gademann, Karl
    Rinsch, Chris
    Schoonjans, Kristina
    Sauve, Anthony A.
    Auwerx, Johan
    [J]. CELL METABOLISM, 2012, 15 (06) : 838 - 847
  • [2] Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
    Fang, Evandro Fei
    Scheibye-Knudsen, Morten
    Brace, Lear E.
    Kassahun, Henok
    SenGupta, Tanima
    Nilsen, Hilde
    Mitchell, James R.
    Croteau, Deborah L.
    Bohr, Vilhelm A.
    [J]. CELL, 2014, 157 (04) : 882 - 896
  • [3] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
    Gomes, Ana P.
    Price, Nathan L.
    Ling, Alvin J. Y.
    Moslehi, Javid J.
    Montgomery, Magdalene K.
    Rajman, Luis
    White, James P.
    Teodoro, Joao S.
    Wrann, Christiane D.
    Hubbard, Basil P.
    Mercken, Evi M.
    Palmeira, Carlos M.
    de Cabo, Rafael
    Rolo, Anabela P.
    Turner, Nigel
    Bell, Eric L.
    Sinclair, David A.
    [J]. CELL, 2013, 155 (07) : 1624 - 1638
  • [4] MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
    Hoeijmakers, Jan H. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (15) : 1475 - 1485
  • [5] Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    Imai, S
    Armstrong, CM
    Kaeberlein, M
    Guarente, L
    [J]. NATURE, 2000, 403 (6771) : 795 - 800
  • [6] The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
    Mouchiroud, Laurent
    Houtkooper, Riekelt H.
    Moullan, Norman
    Katsyuba, Elena
    Ryu, Dongryeol
    Canto, Carles
    Mottis, Adrienne
    Jo, Young-Suk
    Viswanathan, Mohan
    Schoonjans, Kristina
    Guarente, Leonard
    Auwerx, Johan
    [J]. CELL, 2013, 154 (02) : 430 - 441
  • [7] Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
    Ramsey, Kathryn Moynihan
    Mills, Kathryn F.
    Satoh, Akiko
    Imai, Shin-ichiro
    [J]. AGING CELL, 2008, 7 (01) : 78 - 88
  • [8] A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
    Scheibye-Knudsen, Morten
    Mitchell, Sarah J.
    Fang, Evandro F.
    Iyama, Teruaki
    Ward, Theresa
    Wang, James
    Dunn, Christopher A.
    Singh, Nagendra
    Veith, Sebastian
    Hasan-Olive, Md Mahdi
    Mangerich, Aswin
    Wilson, Mark A.
    Mattson, Mark P.
    Bergersen, Linda H.
    Cogger, Victoria C.
    Warren, Alessandra
    Le Couteur, David G.
    Moaddel, Ruin
    Wilson, David M., III
    Croteau, Deborah L.
    de Cabo, Rafael
    Bohr, Vilhelm A.
    [J]. CELL METABOLISM, 2014, 20 (05) : 840 - 855
  • [9] Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
    Shimazu, Tadahiro
    Hirschey, Matthew D.
    Newman, John
    He, Wenjuan
    Shirakawa, Kotaro
    Le Moan, Natacha
    Grueter, Carrie A.
    Lim, Hyungwook
    Saunders, Laura R.
    Stevens, Robert D.
    Newgard, Christopher B.
    Farese, Robert V., Jr.
    de Cabo, Rafael
    Ulrich, Scott
    Akassoglou, Katerina
    Verdin, Eric
    [J]. SCIENCE, 2013, 339 (6116) : 211 - 214
  • [10] Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
    Yoshino, Jun
    Mills, Kathryn F.
    Yoon, Myeong Jin
    Imai, Shin-ichiro
    [J]. CELL METABOLISM, 2011, 14 (04) : 528 - 536
1