Crystal and Molecular Structure Analysis of (2-((6-Chloro pyridin-3-yl)methoxy)-5-methylphenyl) (p-tolyl)Methanone

被引:1
作者
Lakshminarayana, B. N. [1 ]
Prasad, J. Shashidhara [1 ]
Venu, T. D. [2 ]
Manuprasad, B. K. [2 ]
Sridhar, M. A. [1 ]
Shashikanth, Sheena [2 ]
机构
[1] Univ Mysore, Dept Studies Phys, Mysore 570006, Karnataka, India
[2] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
关键词
anti-cancer; anti-inflammatory; benzophenone; crystal structure; pyridine ring; BENZOPHENONE; INHIBITORS; FARNESYLTRANSFERASE;
D O I
10.1080/15421400903359116
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The title compound, (2-((6-chloropyridin-3-yl)methoxy)-5-methylphenyl)(p-tolyl) methanone, was synthesized and characterized spectroscopically and finally confirmed by (XRD) study. The title compound crystallizes in the monoclinic space group P21/c with cell parameters a=9.4420(1)angstrom, b=7.9810(6)angstrom, c=23.777(4)angstrom, =90 degrees, =90.883(3)degrees, =90 degrees, V=1791.5(4)angstrom-3, and Z=4. The structure exhibits intermolecular hydrogen bond of the type C-H center dot center dot center dot O.
引用
收藏
页码:207 / 214
页数:8
相关论文
共 28 条
  • [1] STRUCTURE AND CHEMOTHERAPEUTICAL ACTIVITY OF A POLYISOPRENYLATED BENZOPHENONE FROM THE STEM BARK OF GARCINIA-HUILLENSIS
    BAKANA, P
    CLAEYS, M
    TOTTE, J
    PIETERS, LAC
    VANHOOF, L
    VEMBA, T
    VANDENBERGHE, DA
    VLIETINCK, AJ
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1987, 21 (01) : 75 - 84
  • [2] Benzophenones from Hypericum carinatum
    Bernardi, APM
    Ferraz, ABF
    Albring, DV
    Bordignon, SAL
    Schripsema, J
    Bridi, R
    Dutra-Filho, CS
    Henriques, AT
    von Poser, GL
    [J]. JOURNAL OF NATURAL PRODUCTS, 2005, 68 (05): : 784 - 786
  • [3] Time-resolved resonance Raman identification and structural characterization of a light absorbing transient intermediate in the photoinduced reaction of benzophenone in 2-propanol
    Du, Yong
    Ma, Chensheng
    Kwok, Wai Ming
    Xue, Jiadan
    Phillips, David Lee
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (19) : 7148 - 7156
  • [4] Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors or steroid sulfatase
    Hejaz, HAM
    Woo, LWL
    Purohit, A
    Reed, MJ
    Potter, BVL
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (10) : 2759 - 2772
  • [5] JAQUES M, 1983, Patent No. 79499
  • [6] KATSUICHI S, 1992, CHEM ABSTR 128368G, V116
  • [7] Synthesis and anti-inflammatory activity of benzophenone analogues
    Khanum, SA
    Shashikanth, S
    Deepak, AV
    [J]. BIOORGANIC CHEMISTRY, 2004, 32 (04) : 211 - 222
  • [8] Kumazawa E, 1997, CHEM PHARM BULL, V45, P1470
  • [9] Ras farnesyltransferase: A new therapeutic target
    Leonard, DM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (19) : 2971 - 2990
  • [10] Martin R., 2005, HDB HYDROXYACETOPHEN