Angiogenesis as an immunopharmacologic target in inflammation and cancer

被引：60
作者：
Bian, XW [1 ]
Chen, JH
Jiang, XF
Bai, JS
Wang, QL
Zhang, X
机构：
[1] Third Mil Med Univ, SW Hosp, Inst Pathol, Chongqing 400038, Peoples R China
[2] NCI, Expt Immunol Lab, Canc Res Ctr, Frederick, MD 21702 USA
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2004年 / 4卷 / 12期
基金：
中国国家自然科学基金;
关键词：
angiogenesis; chronic inflammation; cancer; metastasis;
D O I：
10.1016/j.intimp.2004.07.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Many pathological processes including wound healing, chronic inflammation and cancer require angiogenesis, i.e., the formation of new vasculature in the lesions. Accumulating evidence indicates that angiogenesis is crucial for both chronic inflammation and the growth of malignant tumors with the participation of diverse cytokines, chemokines and growth factors. It is nevertheless believed that differences exist in angiogenesis between cancer and chronic inflammatory diseases. The aim of this review is to outline the characteristics of angiogenesis in chronic inflammation and cancer. A better understanding of the angiogenic processes may facilitate the design of more effective therapies for chronic inflammation and cancer. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：1537 / 1547
页数：11
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