SYNTHESIS OF 20-EPI-ELDECALCITOL [20-EPI-1α,25-DIHYDROXY-2β-(3-HYDROXYPROPOXY)VITAMIN D3: 20-EPI-ED-71]

被引：6
|
作者：
Yoshino, Madoka [1 ]
Eto, Kohei [1 ]
Takahashi, Keisuke [1 ]
Ishihara, Jun [1 ]
Hatakeyama, Susumi [1 ]
Ono, Yoshiyuki [2 ]
Saito, Hitoshi [2 ]
Kubodera, Noboru [2 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
[2] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038324, Japan
来源：
HETEROCYCLES | 2010年 / 81卷 / 02期
关键词：
A-RING DIASTEREOMERS; VITAMIN-D ANALOGS; 1-ALPHA; 25-DIHYDROXY-2-BETA-(3-HYDROXYPROPOXY)VITAMIN-D-3; ED-71; 25-DIHYDROXYVITAMIN D-3; OSTEOPOROTIC PATIENTS; EFFICIENT SYNTHESIS; BONE MASS; DESIGN;
D O I：
10.3987/COM-09-11871
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent synthesis of biologically interesting 20-epi-eldecalcitol which possesses an inverted C-21 methyl substituent at the 20-position of the side chain of 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (eldecalcitol) is described.
引用
收藏
页码：381 / 394
页数：14
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