Iron- and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents

被引：56

作者：

Barre, Baptiste ^{[1
]}

Gonnard, Laurine ^{[1
]}

Campagne, Remy ^{[1
]}

Reymond, Sebastien ^{[1
]}

Marin, Julien ^{[2
]}

Ciapetti, Paola ^{[2
]}

Brellier, Marie ^{[2
]}

Guerinot, Amandine ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Res Univ, CNRS, UMR 8231, Lab Chim Organ,Inst Chem Biol & Innovat CBI,ESPCI, F-75231 Paris 05, France

[2] NovAliX, F-67405 Illkirch Graffenstaden, France

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 23期

关键词：

SECONDARY ALKYL-HALIDES; CROSS-COUPLING REACTIONS; ARYL; BROMIDES;

D O I：

10.1021/ol503043r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.

引用

页码：6160 / 6163

页数：4

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