Mesenchymal stromal cells - Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

被引：682

作者：

Kolf, Catherine M. ^{[1
]}

Cho, Elizabeth ^{[1
]}

Tuan, Rocky S. ^{[1
]}

机构：

[1] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, US Dept HHS, Bethesda, MD 20892 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2007年 / 9卷 / 01期

关键词：

D O I：

10.1186/ar2116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.

引用

页数：10

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