Infections due to Candida haemulonii: species identification, antifungal susceptibility and outcomes

被引：51

作者：

Ruan, Sheng-Yuan ^{[2
]}

Kuo, Yao-Wen ^{[2
]}

Huang, Chun-Ta ^{[2
]}

Hsiue, Han-Chung ^{[3
]}

Hsueh, Po-Ren ^{[1
,4
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Internal Med, Yun Lin Branch, Yunlin, Taiwan

[3] Natl Taiwan Univ, Coll Med, Sch Med, Taipei 10764, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2010年 / 35卷 / 01期

关键词：

Candida haemulonii; Identification; Susceptibility; Treatment; AMPHOTERICIN-B-RESISTANT; YEAST; FUNGEMIA; PROBES; BLOOD;

D O I：

10.1016/j.ijantimicag.2009.08.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Here we report the clinical features and treatment outcomes of three patients with Candida haemulonii infection. Candida haemulonii was confirmed by sequence analysis of the internal transcribed spacer (ITS) regions of the rRNA genes and the 18S rRNA genes. Two of the three isolates were associated with fungaemia and reduced susceptibility to fluconazole [minimum inhibitory concentrations (MICs) of 16 mg/L] and amphotericin B (MICs of 2 mg/L). However, one of these two patients responded to fluconazole therapy. Echinocandins, voriconazole and posaconazole demonstrated excellent in vitro potency against the isolates. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：85 / 88

页数：4

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