Single-Molecule Study of Proteins by Biological Nanopore Sensors

被引：12

作者：

Wu, Dongmei ^{[1
]}

Bi, Sheng ^{[2
]}

Zhang, Liyu ^{[1
]}

Yang, Jun ^{[2
]}

机构：

[1] Jiamusi Univ, Coll Pharm, Jiamusi 154007, Peoples R China

[2] Jiamusi Univ, Affiliated Hosp 1, Jiamusi 154007, Peoples R China

来源：

SENSORS | 2014年 / 14卷 / 10期

关键词：

alpha-hemolysin; protein conformation; protein-ligand interactions; new nanopores; ALPHA-HEMOLYSIN; POLYNUCLEOTIDE MOLECULES; TRANSLOCATION; PEPTIDES; PORE; DISCRIMINATION; CHANNEL; DNA;

D O I：

10.3390/s141018211

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of alpha-hemolysin (alpha-HL) nanopores in protein conformation detections and protein-ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions.

引用

页码：18211 / 18222

页数：12

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