Pyridazine derivatives and related compounds.: Part 13:: Synthesis and antimicrobial activity of some pyridazino[3′,4′:3,4]pyrazolo[5,1-c]-1,2,4-triazines

被引：54

作者：

Deeb, A ^{[1
]}

El-Mariah, F

Hosny, M

机构：

[1] Zagazig Univ, Fac Sci, Dept Chem, Zagazig, Egypt

[2] Ain Shams Univ, Dept Chem, Fac Girls, Cairo, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 19期

关键词：

D O I：

10.1016/j.bmcl.2004.06.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A general method for the preparation of substituted pyridazinopyrazolotriazines is reported. 3-Aminopyrazolo[3,4-4-d]pyridazine was diazotized and coupled with active methylene reagents to afford the tricyclic pyridazino[3',4':3,4]pyrazolo[5,1-c]-1,2,4-triazines with substituents such as methyl, phenyl, ethoxycarbonyl, acetyl or benzoyl, depending on the methylene reagent used. In addition several condensation reactions with hydrazines gave the corresponding acid hydrazide and/or hydrazones. Reactions of 3 with aromatic aldehydes afforded hydrazones. The products were screened for their antimicrobial activity against five microorganisms. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5013 / 5017

页数：5

共 7 条

[1]

BUTTER RN, 1975, CHEM REV, V75, P241

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