Dye-Loaded Ferritin Nanocages for Multimodal Imaging and Photothermal Therapy

被引：276

作者：

Huang, Peng ^{[1
]}

Rong, Pengfei ^{[1
,2
,3
]}

Jin, Albert ^{[4
]}

Yan, Xuefeng ^{[1
]}

Zhang, Molly Gu ^{[1
]}

Lin, Jing ^{[1
]}

Hu, Hao ^{[1
]}

Wang, Zhe ^{[1
,5
]}

Yue, Xuyi ^{[1
,5
]}

Li, Wanwan ^{[1
]}

Niu, Gang ^{[1
]}

Zeng, Wenbin ^{[2
]}

Wang, Wei ^{[3
]}

Zhou, Kechao ^{[2
]}

Chen, Xiaoyuan ^{[1
]}

机构：

[1] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[2] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China

[3] Cent S Univ, Dept Radiol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

[4] NIBIB, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD 20892 USA

[5] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Fujian, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 37期

基金：

美国国家科学基金会;

关键词：

theranostics; ferritin; fluorescence imaging; photoacoustic imaging; photothermal therapy; GOLD NANORODS; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; IN-VITRO; NANOPARTICLES; AGENT; PHOTOSENSITIZERS; NANOVESICLES; NANOCRYSTALS; CHEMOTHERAPY;

D O I：

10.1002/adma.201400914

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multimodal imaging-guided photothermal therapy (PTT), for the therapy of cancer, based on a ferritin (FRT) nanocage loaded with the near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles of DFRT (in imaging and PTT) are successfully balanced by using two different excitation wavelengths: 550 nm for high quantum-yield fluorescence imaging on the one hand and 808 nm for photoacoustic imaging and PTT with high photothermal conversion efficiency on the other. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6401 / 6408

页数：8

共 40 条

[1] PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy [J].

Cheng, Liang ;

He, Weiwei ;

Gong, Hua ;

Wang, Chao ;

Chen, Qian ;

Cheng, Zhengping ;

Liu, Zhuang .

ADVANCED FUNCTIONAL MATERIALS, 2013, 23 (47) :5893-5902

[2] Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green [J].

Fernandez-Fernandez, Alicia ;

Manchanda, Romila ;

Lei, Tingjun ;

Carvajal, Denny A. ;

Tang, Yuan ;

Kazmi, Syed Zahid Raza ;

McGoron, Anthony J. .

MOLECULAR IMAGING, 2012, 11 (02) :99-113

[3] Supramolecular adducts of squaraine and protein for noninvasive tumor imaging and photothermal therapy in vivo [J].

Gao, Fu-Ping ;

Lin, Yao-Xin ;

Li, Li-Li ;

Liu, Ya ;

Mayerhoeffer, Ulrich ;

Spenst, Peter ;

Su, Ji-Guo ;

Li, Jing-Yuan ;

Wuerthner, Frank ;

Wang, Hao .

BIOMATERIALS, 2014, 35 (03) :1004-1014

[4] Copper Selenide Nanocrystals for Photothermal Therapy [J].

Hessel, Colin M. ;

Pattani, Varun P. ;

Rasch, Michael ;

Panthani, Matthew G. ;

Koo, Bonil ;

Tunnell, James W. ;

Korgel, Brian A. .

NANO LETTERS, 2011, 11 (06) :2560-2566

[5] Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics [J].

Huang, Peng ;

Rong, Pengfei ;

Lin, Jing ;

Li, Wanwan ;

Yan, Xuefeng ;

Zhang, Molly Gu ;

Nie, Liming ;

Niu, Gang ;

Lu, Jie ;

Wang, Wei ;

Chen, Xiaoyuan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (23) :8307-8313

[6] Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy [J].

Huang, Peng ;

Lin, Jing ;

Li, Wanwan ;

Rong, Pengfei ;

Wang, Zhe ;

Wang, Shouju ;

Wang, Xiaoping ;

Sun, Xiaolian ;

Aronova, Maria ;

Niu, Gang ;

Leapman, Richard D. ;

Nie, Zhihong ;

Chen, Xiaoyuan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (52) :13958-13964

[7] Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy [J].

Huang, Peng ;

Lin, Jing ;

Wang, Shouju ;

Zhou, Zhijun ;

Li, Zhiming ;

Wang, Zhe ;

Zhang, Chunlei ;

Yue, Xuyi ;

Niu, Gang ;

Yang, Min ;

Cui, Daxiang ;

Chen, Xiaoyuan .

BIOMATERIALS, 2013, 34 (19) :4643-4654

[8] Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy [J].

Huang, Peng ;

Lin, Jing ;

Wang, Xiansong ;

Wang, Zhe ;

Zhang, Chunlei ;

He, Meng ;

Wang, Kan ;

Chen, Feng ;

Li, Zhiming ;

Shen, Guangxia ;

Cui, Daxiang ;

Chen, Xiaoyuan .

ADVANCED MATERIALS, 2012, 24 (37) :5104-5110

[9] Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy [J].

Huang, Peng ;

Bao, Le ;

Zhang, Chunlei ;

Lin, Jing ;

Luo, Teng ;

Yang, Dapeng ;

He, Meng ;

Li, Zhiming ;

Gao, Guo ;

Gao, Bing ;

Fu, Shen ;

Cui, Daxiang .

BIOMATERIALS, 2011, 32 (36) :9796-9809

[10] Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy [J].

Huang, Peng ;

Xu, Cheng ;

Lin, Jing ;

Wang, Can ;

Wang, Xiansong ;

Zhang, Chunlei ;

Zhou, Xuejiao ;

Guo, Shouwu ;

Cui, Daxiang .

THERANOSTICS, 2011, 1 :240-250

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