Comparison of Clostridioides difficile strains from animals and humans: First results after introduction of C. difficile molecular typing and characterization at the Istituto Zooprofilattico Sperimentale of Piemonte, Liguria e Valle d'Aosta, Italy

被引：2

作者：

Tramuta, Clara ^{[1
]}

Spigaglia, Patrizia ^{[2
]}

Barbanti, Fabrizio ^{[2
]}

Bianchi, Daniela Manila ^{[1
]}

Boteva, Cvetelina ^{[1
]}

Di Blasio, Alessia ^{[3
]}

Zoppi, Simona ^{[3
]}

Zaccaria, Teresa ^{[4
]}

Proroga, Yolande Therese Rose ^{[5
]}

Chiavacci, Laura ^{[6
]}

Dondo, Alessandro ^{[3
]}

Decastelli, Lucia ^{[1
]}

机构：

[1] Ist Zooprofilatt Sperimentale Piemonte Liguria &, SC Sicurezza & Qualith Alimenti, Via Bologna 148, I-10154 Turin, Italy

[2] Ist Super Sanita, Dipartimento Malattie Infett, Rome, Italy

[3] Ist Zooprofilatt Sperimentale Piemonte Liguria &, SC Diagnost Gen, Turin, Italy

[4] Azienda Osped Univ, Lab Microbiol & Virol, Turin, Italy

[5] Ist Zooprofilatt Sperimentale Mezzogiorno, Dipartimento Ispez Alimenti, Portici, NA, Italy

[6] Ist Zooprofilatt Sperimentale Piemonte Liguria &, SC Epidemiol Anal Rischio, Turin, Italy

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2021年 / 75卷

关键词：

Clostridioides difficile; Molecular characterization; PCR-ribotyping; One Health; FIELD GEL-ELECTROPHORESIS; TANDEM-REPEAT ANALYSIS; ECONOMIC BURDEN; PCR RIBOTYPES; TOXINOTYPE-V; INFECTION; EPIDEMIOLOGY; PREVALENCE; FOOD; RESISTANCE;

D O I：

10.1016/j.cimid.2021.101623

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PCR ribotypes (RTs027 and 078) are known causes of Clostridioides difficile infection (CDI) in humans. Molecular typing and characterization of 39 C. difficile strains isolated from samples from humas and animals in 2016?2018 indicated an overlap of RTs between community-acquired patients (CA-CDI) and domestic animals from the same geographical area; 14 RTs were identified: 12 RTs were positive for toxins A/B; RT078, RT080 and RT126 were also positive for binary toxin (CDT). Most of the RTs from the animals (RTs020, 078, 106, 126) were also detected in the samples from humans. Strains grouped into three clusters: cluster I included prevalently human strains, mainly RT 018; clusters II and III included strains from humans and animals, mainly RT078 and RT020. The CA-CDI strains suggested animals as a reservoir of C. difficile isolated together with other microorganisms from animals, highlighting the association of enteric pathogens as a cause of infection and death.

引用

页数：6