Biocompatible Prussian blue nanoparticles: Preparation, stability, cytotoxicity, and potential use as an MRI contrast agent

被引:131
作者
Shokouhimehr, Mohammadreza [1 ]
Soehnlen, Eric S. [1 ]
Khitrin, Anatoly [1 ]
Basu, Soumitra [1 ]
Huang, Songping D. [1 ]
机构
[1] Kent State Univ, Dept Chem, Kent, OH 44240 USA
关键词
Prussian blue; Nanoparticles; Magnetic properties; Contrast agents; Magnetic resonance imaging; MAGNETIC NANOPARTICLES; CYANIDE; MICROEMULSIONS; TRANSITION; POLYMERS; ANALOGS; DESIGN; ROUTE; NI;
D O I
10.1016/j.inoche.2009.10.015
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A simple synthetic procedure for preparing biocompatible superparamagnetic Prussian blue (PB) nanoparticles is reported. The stability, cytotoxicity and ability for PB nanoparticles to penetrate cells are investigated. The potential of using PB nanoparticles as the T-1-weighted MRI contrast agent is demonstrated. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:58 / 61
页数:4
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