Adenocarcinoma of Barrett's esophagus in a dog

被引：7

作者：

Chambers, James K. ^{[1
]}

Saito, Tsubasa ^{[1
]}

Fukushima, Kenjiro ^{[2
]}

Kakuta, Shigeru ^{[3
]}

Nakayama, Jun ^{[4
]}

Ohno, Koichi ^{[5
]}

Tsujimoto, Hajime ^{[5
]}

Nakayama, Hiroyuki ^{[1
]}

Uchida, Kazuyuki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Vet Pathol, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Vet Med Ctr, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Biomed Sci, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

[4] Shinshu Univ, Dept Mol Pathol, Grad Sch Med, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan

[5] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Vet Internal Med, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

来源：

JOURNAL OF TOXICOLOGIC PATHOLOGY | 2017年 / 30卷 / 03期

基金：

日本学术振兴会;

关键词：

adenocarcinoma; Barrett's esophagus; dog; INTESTINAL METAPLASIA; HELICOBACTER-PYLORI; EXPRESSION; INFECTION; CANCER; P53;

D O I：

10.1293/tox.2017-0009

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

An endoscopic examination revealed a mass in the distal esophagus of a 9-year-old intact male bulldog. Histopathologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells and extended from the squamous epithelium of the esophageal mucosa, indicating that the tumor was derived from Barrett's esophagus. Moreover, highly atypical foci that exhibited a cribriform pattern and high mitotic indices were also observed. The epithelial cells on the surface of the lesion often produced mucus that was positive for Alcian blue and immunohistochemically positive for MUC5AC. The neoplastic epithelial cells were diffusely positive for cytokeratin 7 and p53, and occasionally positive for cytokeratin 20. Based on these findings, the tumor was diagnosed as an adenocarcinoma. This report describes the clinical and pathological features of a spontaneous case of adenocarcinoma of Barrett's esophagus in a dog.

引用

页码：239 / 243

页数：5

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