Enantioselective synthesis of highly functionalised amides by copper-catalysed vinylogous Mukaiyama aldol reaction

被引：47

作者：

Frings, Marcus ^{[1
]}

Goedert, Daniel ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 30期

关键词：

LEWIS-BASE ACTIVATION; C-1-SYMMETRIC AMINOSULFOXIMINES; REVISED STRUCTURES; ADDITION-REACTIONS; NATURAL-PRODUCTS; MANNICH REACTION; PALMEROLIDE-A; LIGANDS; SULFOXIMINES; ALDEHYDES;

D O I：

10.1039/c0cc00996b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amides with quaternary stereogenic centers have been synthesised by catalytic asymmetric vinylogous Mukaiyama aldol reactions. The chiral copper-sulfoximine catalyst gives rise to products with moderate to good yields and up to 92% ee.

引用

页码：5497 / 5499

页数：3

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