Synthesis and biological evaluation of analogues of bacterial lipid I

被引：0

作者：

Silva, DJ

Bowe, CL

Branstrom, AA

Baizman, ER

Sofia, RJ

机构：

[1] Incara Res Labs, Dept Chem, Cranbury, NJ 08536 USA

[2] Incara Res Labs, Dept Biol Res, Cranbury, NJ 08536 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 24期

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D O I：

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中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bacterial Lipid I analogues containing different anomeric groups at the muramic acid moiety were synthesized and screened in MurG enzyme assays run in the presence and absence of cell wall membranes. The results obtained in this study help elucidate the role of the lipid diphosphate in the recognition of Lipid I by MurG. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2811 / 2813

页数：3

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