COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM)

被引：37

作者：

Bonadonna, Patrizia ^{[1
]}

Brockow, Knut ^{[2
]}

Niedoszytko, Marek ^{[3
]}

Elberink, Hanneke Oude ^{[4
]}

Akin, Cem ^{[5
]}

Nedoszytko, Boguslaw ^{[6
]}

Butterfield, Joseph H. ^{[7
]}

Alvarez-Twose, Ivan ^{[8
,9
]}

Sotlar, Karl ^{[10
]}

Schwaab, Juliana ^{[11
]}

Jawhar, Mohamad ^{[12
]}

Castells, Mariana ^{[13
]}

Sperr, Wolfgang R. ^{[14
,15
]}

Hermine, Olivier ^{[16
]}

Gotlib, Jason ^{[17
]}

Zanotti, Roberta ^{[18
]}

Reiter, Andreas ^{[19
]}

Broesby-Olsen, Sigurd ^{[20
,21
,22
,23
]}

Bindslev-Jensen, Carsten ^{[20
,21
,22
,23
]}

Schwartz, Lawrence B. ^{[24
]}

Horny, Hans-Peter ^{[25
]}

Radia, Deepti ^{[26
]}

Triggiani, Massimo ^{[27
]}

Sabato, Vito ^{[28
,29
]}

Carter, Melody C. ^{[30
]}

Siebenhaar, Frank ^{[31
,32
,33
,34
]}

Orfao, Alberto ^{[35
]}

Grattan, Clive ^{[36
]}

Metcalfe, Dean D. ^{[30
]}

Arock, Michel ^{[37
]}

Gulen, Theo ^{[38
,39
,40
]}

Hartmann, Karin ^{[40
,41
,42
,43
]}

Valent, Peter ^{[14
,15
]}

机构：

[1] Verona Univ Hosp, Allergy Unit, Verona, Italy

[2] Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany

[3] Med Univ Gdansk, Dept Allergol, Gdansk, Poland

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Sect Allergy, Groningen, Netherlands

[5] Univ Michigan, Div Allergy & Clin Immunol, Ann Arbor, MI 48109 USA

[6] Med Univ Gdansk, Dept Dermatol, Gdansk, Poland

[7] Mayo Clin, Div Allerg Dis, Rochester, MN USA

[8] Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, Toledo, Spain

[9] Hosp Virgen del Valle, CIBERONC, Toledo, Spain

[10] Paracelsus Med Univ Salzburg, Inst Pathol, Salzburg, Austria

[11] Heidelberg Univ, Univ Hosp Mannheim, Mannheim, Germany

[12] Heidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany

[13] Harvard Med Sch, Mastocytosis Ctr, Brigham & Womens Hosp, Boston, MA 02115 USA

[14] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[15] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[16] Univ Paris 05, Ctr Natl Reference Mastocytoses, Imagine Inst, Sorbonne Paris Cite, Paris, France

[17] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

[18] Verona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy

[19] Heidelberg Univ, Univ Med Mannheim, Med Klin 3, Mannheim, Germany

[20] Odense Univ Hosp, Mastocytosis Ctr, Odense, Denmark

[21] Odense Univ Hosp, Dept Dermatol, Odense, Denmark

[22] Odense Univ Hosp, Allergy Ctr, Odense, Denmark

[23] Odense Univ Hosp, Odense Res Ctr Anaphylaxis, Odense, Denmark

[24] Virginia Commonwealth Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA USA

[25] Ludwig Maximilians Univ Munchen, Inst Pathol, Munich, Germany

[26] Guys & St Thomas NHS Hosp, Dept Clin Haematol, London, England

[27] Univ Salerno, Dept Med, Div Allergy & Clin Immunol, Salerno, Italy

[28] Univ Antwerp, Fac Med & Hlth Sci, Dept Immunol Allergol Rheumatol, Antwerp, Belgium

[29] Antwerp Univ Hosp, Antwerp, Belgium

[30] NIAID, Lab Allerg Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[31] Charite Univ Med Berlin, Dept Dermatol & Allergy, Dermatol Allergol, Berlin, Germany

[32] Free Univ Berlin, Berlin, Germany

[33] Humboldt Univ, Berlin, Germany

[34] Berlin Inst Hlth, Berlin, Germany

[35] IBSAL, Serv Cent Citometria, Ctr Invest Canc IBMCC CSIC USAL, Salamanca, Spain

[36] Guys Hosp, St Johns Inst Dermatol, London, England

[37] Paris Sorbonne Univ, Piti Salpetriere Hosp, Dept Hematol Biol, Paris, France

[38] Karolinska Univ Hosp Huddinge, Dept Resp Med & Allergy, Stockholm, Sweden

[39] Karolinska Inst, Dept Med Solna, Stockholm, Sweden

[40] Univ Cologne, Dept Dermatol, Cologne, Germany

[41] Univ Hosp Basel, Dept Dermatol, Div Allergy, Basel, Switzerland

[42] Univ Basel, Basel, Switzerland

[43] Univ Hosp Basel, Dept Biomed, Basel, Switzerland

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2021年 / 9卷 / 06期

基金：

美国国家卫生研究院; 奥地利科学基金会;

关键词：

Vaccine; COVID-19; Mastocytosis; Mast cell diseases; Adverse reaction to medications; Hypersensitivity reactions; HYMENOPTERA VENOM ALLERGY; SYSTEMIC MASTOCYTOSIS; FATAL ANAPHYLAXIS; RISK; CLASSIFICATION; DISORDERS; PREVENTION; MANAGEMENT; SYMPTOMS; HYPERSENSITIVITY;

D O I：

10.1016/j.jaip.2021.03.041

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Coronavirus disease 2019 (COVID-19) is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against COVID-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of COVID-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of COVID-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and postvaccination observation, should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations, and expert opinion that form the basis of these recommendations. (C) 2021 American Academy of Allergy, Asthma & Immunology

引用

页码：2139 / 2144

页数：6

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