Germinal center derived B cell memory without T cells

被引:1
作者
Zhang, Yang [1 ]
Toellner, Kai-Michael [1 ]
机构
[1] Univ Birmingham, Inst Immunol & Immunotherapy, Med Sch, Birmingham, W Midlands, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1084/jem.20220012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Liu et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210527) in this issue show that T cell-independent germinal centers (GCs) can produce long-lived memory and plasma cell output. This may help explain how polysaccharide antigens provide long-term protection.
引用
收藏
页数:2
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共 21 条
[1]   Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5 [J].
Allen, CDC ;
Ansel, KM ;
Low, C ;
Lesley, R ;
Tamamura, H ;
Fujii, N ;
Cyster, JG .
NATURE IMMUNOLOGY, 2004, 5 (09) :943-952
[2]   A quasi-monoclonal mouse [J].
Cascalho, M ;
Ma, A ;
Lee, S ;
Masat, L ;
Wabl, M .
SCIENCE, 1996, 272 (5268) :1649-1652
[3]   Germinal centers without T cells [J].
de Vinuesa, CG ;
Cook, MC ;
Ball, J ;
Drew, M ;
Sunners, Y ;
Cascalho, M ;
Wabl, M ;
Klaus, GGB ;
MacLennan, ICM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (03) :485-493
[4]   T cell-independent B cell memory [J].
Defrance, Thierry ;
Taillardet, Morgan ;
Genestier, Laurent .
CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (03) :330-336
[5]   The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry [J].
Dominguez-Sola, David ;
Victora, Gabriel D. ;
Ying, Carol Y. ;
Phan, Ryan T. ;
Saito, Masumichi ;
Nussenzweig, Michel C. ;
Dalla-Favera, Riccardo .
NATURE IMMUNOLOGY, 2012, 13 (11) :1083-1091
[6]   T-Independent Antibody Responses to T-Dependent Antigens: A Novel Follicular Dendritic Cell-Dependent Activity [J].
El Shikh, Mohey Eldin M. ;
El Sayed, Rania M. ;
Szakal, Andras K. ;
Tew, John G. .
JOURNAL OF IMMUNOLOGY, 2009, 182 (06) :3482-3491
[7]   Clonal selection in the germinal centre by regulated proliferation and hypermutation [J].
Gitlin, Alexander D. ;
Shulman, Ziv ;
Nussenzweig, Michel C. .
NATURE, 2014, 509 (7502) :637-+
[8]   B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses [J].
Hsu, MC ;
Toellner, KM ;
Vinuesa, CG ;
MacLennan, ICM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) :5905-5910
[9]   Mechanisms underpinning poor antibody responses to vaccines in ageing [J].
Lee, Jia Le ;
Linterman, Michelle A. .
IMMUNOLOGY LETTERS, 2022, 241 :1-14
[10]   T-independent antigen induces humoral memory through germinal centers [J].
Liu, Xin ;
Zhao, Yongshan ;
Qi, Hai .
JOURNAL OF EXPERIMENTAL MEDICINE, 2022, 219 (03)