Following a Science and Engineering collection weeding project of over 350,000 print items, our research team conducted interviews with 20 library employees and 19 teaching faculty involved in the project. The purpose of the interviews was to assess the interviewees' perspectives and feelings relating to the time required to complete the project, inter- and intra- library communication, the decision-making processes, and their personal assessment of the costs and benefits of the project. The interviewees also offered their views of the overall project's successes and areas for improvement. Drawing from a qualitative analysis of the interviews, we provide guidance for other academic libraries preparing to undertake their own collection weeding projects including suggestions for what to expect and what to manage throughout the process.