Effect of the RET Inhibitor Vandetanib in a Patient With RET Fusion-Positive Metastatic Non-Small-Cell Lung Cancer

被引:43
作者
Falchook, Gerald S. [1 ]
Ordonez, Nelson G. [1 ]
Bastida, Christel C. [1 ]
Stephens, Philip J. [2 ]
Miller, Vincent A. [2 ]
Gaido, Lindsay [1 ]
Jackson, Tiffiny [1 ]
Karp, Daniel D. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] Fdn Med, Cambridge, MA USA
关键词
PHASE-III TRIAL; DOUBLE-BLIND; PLUS DOCETAXEL; PROTOONCOGENE; NEOPLASIA; RECEPTOR; GENE; ACTIVATION; EXPRESSION; DIAGNOSIS;
D O I
10.1200/JCO.2013.50.5016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:E141 / E144
页数:4
相关论文
共 28 条
[1]   RET and NTRK1 proto-oncogenes in human diseases [J].
Albert, L ;
Carniti, C ;
Miranda, C ;
Roccato, E ;
Pierotti, MA .
JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (02) :168-186
[2]   A Phase I Study of Vandetanib in Combination with Vinorelbine/Cisplatin or Gemcitabine/Cisplatin as First-Line Treatment for Advanced Non-small Cell Lung Cancer [J].
Blackhall, Fiona H. ;
O'Brien, Mary ;
Schmid, Peter ;
Nicolson, Marianne ;
Taylor, Paul ;
Milenkova, Tsveta ;
Kennedy, Sarah J. ;
Thatcher, Nick .
JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (08) :1285-1288
[3]  
Carlomagno F, 2002, CANCER RES, V62, P7284
[4]   Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer [J].
Dawson, DM ;
Lawrence, EG ;
MacLennan, GT ;
Amini, SB ;
Kung, HJ ;
Robinson, D ;
Resnick, MI ;
Kursh, ED ;
Pretlow, TP ;
Pretlow, TG .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (07) :519-523
[5]   An open-label study of vandetanib with pemetrexed in patients with previously treated non-small-cell lung cancer [J].
de Boer, R. ;
Humblet, Y. ;
Wolf, J. ;
Nogova, L. ;
Ruffert, K. ;
Milenkova, T. ;
Smith, R. ;
Godwood, A. ;
Vansteenkiste, J. .
ANNALS OF ONCOLOGY, 2009, 20 (03) :486-491
[6]   Vandetanib Plus Pemetrexed for the Second-Line Treatment of Advanced Non-Small-Cell Lung Cancer: A Randomized, Double-Blind Phase III Trial [J].
de Boer, Richard H. ;
Arrieta, Oscar ;
Yang, Chih-Hsin ;
Gottfried, Maya ;
Chan, Valorie ;
Raats, Johann ;
de Marinis, Filippo ;
Abratt, Raymond P. ;
Wolf, Juergen ;
Blackhall, Fiona H. ;
Langmuir, Peter ;
Milenkova, Tsveta ;
Read, Jessica ;
Vansteenkiste, Johan F. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (08) :1067-1074
[7]   Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas [J].
Drilon, Alexander ;
Wang, Lu ;
Hasanovic, Adnan ;
Suehara, Yoshiyuki ;
Lipson, Doron ;
Stephens, Phil ;
Ross, Jeffrey ;
Miller, Vincent ;
Ginsberg, Michelle ;
Zakowski, Maureen F. ;
Kris, Mark G. ;
Ladanyi, Marc ;
Rizvi, Naiyer .
CANCER DISCOVERY, 2013, 3 (06) :630-635
[8]   RET proto-oncogene in the development of human cancer [J].
Eng, C .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (01) :380-393
[9]   Distinct Patterns of Cytokine and Angiogenic Factor Modulation and Markers of Benefit for Vandetanib and/or Chemotherapy in Patients With Non-Small-Cell Lung Cancer [J].
Hanrahan, Emer O. ;
Lin, Heather Y. ;
Kim, Edward S. ;
Yan, Shaoyu ;
Du, Danny Z. ;
McKee, Kathryn S. ;
Tran, Hai T. ;
Lee, J. Jack ;
Ryan, Anderson J. ;
Langmuir, Peter ;
Johnson, Bruce E. ;
Heymach, John V. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (02) :193-201
[10]   Baseline Vascular Endothelial Growth Factor Concentration as a Potential Predictive Marker of Benefit from Vandetanib in Non-Small Cell Lung Cancer [J].
Hanrahan, Emer O. ;
Ryan, Anderson J. ;
Mann, Helen ;
Kennedy, Sarah J. ;
Langmuir, Peter ;
Natale, Ronald B. ;
Herbst, Roy S. ;
Johnson, Bruce E. ;
Heymach, John V. .
CLINICAL CANCER RESEARCH, 2009, 15 (10) :3600-3609