Review: Aberrant EVI1 expression in acute myeloid leukaemia

被引：58
作者：
Hinai, Adil A. [1 ]
Valk, Peter J. M. [1 ]
机构：
[1] Erasmus Univ, Dept Haematol, Med Ctr, Room Nc806,Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 172卷 / 06期
关键词：
EVI1; ecotropic virus integration site 1; AML; acute myeloid leukaemia; expression; prognosis; ZINC-FINGER PROTEIN; VIRAL INTEGRATION SITE; HIGH BRE EXPRESSION; TRANSFORMING GENE; CONSENSUS SEQUENCE; SELF-RENEWAL; PR DOMAIN; BINDING; CELL; DNA;
D O I：
10.1111/bjh.13898
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Deregulated expression of the ecotropic virus integration site 1 (EVI1) gene is the molecular hallmark of therapy-resistantmyeloid malignancies bearing chromosomal inv(3)(q21q262) or t(3;3)(q21;q262) [hereafter referred to as inv(3)/t(3;3)] abnormalities. EVI1 is a haematopoietic stemness and transcription factor with chromatin remodelling activity. Interestingly, the EVI1 gene also shows overexpression in 6-11% of adult acute myeloid leukaemia (AML) cases that do not carry any 3q aberrations. Deregulated expression of EVI1 is strongly associated with monosomy 7 and 11q23 abnormalities, which are known to be associated with poor response to treatment. However, EVI1 overexpression has been revealed as an important independent adverse prognostic marker in adult AML and defines distinct risk categories in 11q23-rearranged AML. Recently, important progress has been made in the delineation of the mechanism by which EVI1 becomes deregulated in inv(3)/t(3;3) as well as the cooperating mutations in this specific subset of AML with dismal prognosis.
引用
收藏
页码：870 / 878
页数：9
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