11C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles

被引：5

作者：

Liger, Francois ^{[1
]}

Cadarossanesaib, Florence ^{[1
]}

Iecker, Thibaut ^{[1
]}

Tourvieille, Christian ^{[1
]}

Le Bars, Didier ^{[1
,2
]}

Billard, Thierry ^{[1
,2
]}

机构：

[1] CERMEP In Vivo imaging, 59 Bd Pinel, F-69677 Lyon, France

[2] Univ Lyon 1, Univ Lyon, Inst Chem & Biochem, CNRS,UMR 5246, 43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 41期

关键词：

Carbon-11; Heterocycles; Radiochemistry; Radiolabeling; Positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; AUTOMATED RADIOSYNTHESIS; MEDIATED SYNTHESIS; RECEPTOR AGONIST; PET; BIODISTRIBUTION; CARBONYLATION; RADIOLIGAND; LIGAND;

D O I：

10.1002/ejoc.201901386

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [C-11]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 minutes.

引用

页码：6968 / 6972

页数：5

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