Interferon-Alpha Induced and Ribavirin Induced Thyroid Dysfunction in Patients with Chronic Hepatitis C

被引：0
作者：
Nadeem, Amina [1 ]
Hussain, Muhammad Mazhar [1 ]
Aslam, Muhammad [2 ]
Hussain, Tassawar [3 ]
机构：
[1] Army Med Coll, Dept Physiol, Rawalpindi, Pakistan
[2] Shifa Coll Med, Dept Physiol, Islamabad, Pakistan
[3] Hearts Int Hosp, Islamabad, Pakistan
来源：
HEPATITIS MONTHLY | 2010年 / 10卷 / 02期
关键词：
Chronic Hepatitis C; Interferon; Ribavirin; Thyroid Disease; CHRONIC VIRAL-HEPATITIS; VIRUS-INFECTION; PEGYLATED INTERFERON; AUTOANTIBODY PATTERN; NATURAL-HISTORY; THERAPY; HYPOTHYROIDISM; DISEASE; DISORDERS; RISK;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Chronic hepatitis C (CHC) is one of the commonest infectious diseases of the liver and may lead to cirrhosis or hepatocellular carcinoma. Combination therapy with pegylated interferon (PEG-IFN) and Ribavirin is the treatment of choice for CHC. Combination therapy is thought to act by means of antiviral mechanisms and immunomodulation. Thyroid dysfunction is the most common autoimmune adverse effect associated with combination therapy; hypothyroidism is more common than hyperthyroidism. Antithyroid antibodies and female sex have a predictive value in the development of interferon induced thyroid disease (IITD). Patients with CHC should be informed of the possibility of side effects on the thyroid gland. Screening for antithyroid antibodies and thyroid function tests should be performed in patients with CHC before the commencement of antiviral treatment, and during and after it. This article reviews different aspects of IITD, including its pathogenesis, clinical manifestations, association with treatment regimens and treatment response and the outcome of thyroid dysfunction.
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收藏
页码：132 / 140
页数：9
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