Chemistry and biology of nuciferine

被引：13

作者：

Huang, Xiaobo ^{[1
]}

Hao, Nan ^{[2
]}

Chen, Genqiang ^{[1
]}

Liu, Shengming ^{[1
]}

Che, Zhiping ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Coll Hort & Plant Protect, Luoyang 471023, Henan, Peoples R China

[2] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2022年 / 179卷

基金：

中国国家自然科学基金;

关键词：

Nuciferine; Nelumbo nucifera Gaertn; Synthesis; Anti-hyperlipidemia and anti-obesity; Metabolism; LOTUS NELUMBO-NUCIFERA; LIQUID-CHROMATOGRAPHY; APORPHINE ALKALOIDS; TISSUE DISTRIBUTION; IN-VITRO; LEAVES; IDENTIFICATION; METABOLISM; EXTRACTION; GAERTN;

D O I：

10.1016/j.indcrop.2022.114694

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Nuciferine is an aporphine alkaloid first isolated from Nelumbo nucifera Gaertn as the main bioactive ingredient. Additionally, it was also obtained from some other plants. Nuciferine exhibited diverse bioactivities such as antihyperlipidemic, anti-obesity, anti-fatty liver, antidiabetic, anti-hyperuricemic, antitumor, anti-inflammatory, antiviral, antioxidant activity, and thus has tremendous potential to be developed into drugs. This overview comprehensively summarized the widespread knowledge regarding to the chemistry and biology of nuciferine including isolation techniques, total synthesis, structural modification and structure-activity relationships, bioactivities, metabolism in vivo, and biosynthesis. Furthermore, an expectation was prospectively made for the future research on nuciferine through a careful analysis of the related literature up to early February 2022 and on the strength of our expertise in chemistry and biology of natural products.

引用

页数：16

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