Argyrophilic grain disease: Synergistic component of dementia?

被引:0
作者
Wallon, D. [1 ]
Sommervogel, C. [2 ]
Laquerriere, A. [3 ]
Martinaud, O. [1 ]
Lecourtois, M. [4 ]
Hannequin, D. [1 ,4 ]
机构
[1] Univ Rouen, CHU Charles Nicolle, Serv Neurol, F-76031 Rouen, France
[2] CHR Havre, Serv Geriatrie, F-76083 Le Havre, France
[3] Univ Rouen, CHU Charles Nicolle, Lab Anat & Cytol Pathol, F-76031 Rouen, France
[4] Univ Rouen, Fac Med, INSERM, U614, F-76183 Rouen, France
关键词
Argyrophilic grain disease; Dementia; Alzheimer Disease; Neuropathology; Tau; P62; ALZHEIMERS-DISEASE; BALLOONED NEURONS; ONSET DEMENTIA; PATHOLOGY; FEATURES;
D O I
10.1016/j.neurol.2009.10.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction. Argyrophilic grain disease (AGD) is one cause of neurodegenerative dementia with a variable clinical spectrum. A neuropathology study is required for diagnosis. Case report. We report the case of a 68-year-old patient presenting with cognitive decline associating with frontal dysfunction and parkinsonism. Death occurred two years after onset. The neuropathology study revealed a status criblosus in the basal ganglia, neurofibrillary tangles and AGD. Discussion. We suggest that AGD could explain the atypical course of this dementia considering the fast cognitive decline, the clinical expression and the topography of the lesions. Conclusion. - This case illustrates the possible synergistic deleterious effect of this pathology on other causes of dementia. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:428 / 432
页数:5
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