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Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury
被引:6
作者:
Lipcsey, Miklos
[1
]
Bergquist, Maria
[2
]
Siren, Rebecca
[3
]
Larsson, Anders
[4
]
Huss, Fredrik
[5
,6
]
Pravda, Jay
[7
]
Furebring, Mia
[8
]
Sjolin, Jan
[8
]
Janols, Helena
[8
]
机构:
[1] Uppsala Univ, Dept Surg Sci, Hedenstierna Lab, S-75185 Uppsala, Sweden
[2] Uppsala Univ, Dept Med Sci, Clin Physiol, S-75185 Uppsala, Sweden
[3] Danderyd Hosp, Dept Med, S-18288 Stockholm, Sweden
[4] Uppsala Univ, Dept Med Sci, Clin Chem, S-75185 Uppsala, Sweden
[5] Uppsala Univ Hosp, Burn Ctr, Dept Plast & Maxillofacial Surg, S-75185 Uppsala, Sweden
[6] Uppsala Univ, Dept Surg Sci, Plast Surg, S-75185 Uppsala, Sweden
[7] Therashock LLC, Inflammatory Dis Res Ctr, Palm Beach Gardens, FL 33410 USA
[8] Uppsala Univ, Dept Med Sci, Sect Infect Dis, S-75185 Uppsala, Sweden
关键词:
hydrogen peroxide;
H2O2;
sepsis;
shock;
burn injury;
TBSA;
mortality;
AKI;
hypermetabolism;
ENDOTHELIAL OXIDATIVE STRESS;
T-LYMPHOCYTES;
DEFINITIONS;
DEPLETION;
D O I:
10.3390/biomedicines10040848
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Hydrogen peroxide (H2O2) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H2O2 concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling sepsis-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects. The mean concentrations of H2O2 were found to be lower in patients with severe infections compared to burn injury patients and healthy subjects. Patients with acute kidney injury (AKI), vs. those without AKI, in all diagnostic groups displayed higher concentrations of urine H2O2 (p < 0.001). Likewise, urine concentrations of H2O2 were higher in non-survivors as compared to survivors (p < 0.001) at day 28 in all diagnostic groups, as well as in patients with severe infections and burn injury (p < 0.001 for both). In this cohort, increased H2O2 in urine is thus associated with mortality in patients with sepsis and septic shock as well as in patients with burn injury.
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