Total synthesis of pyridovericin

被引：20

作者：

Irlapati, NR

Adlington, RM

Conte, A

Pritchard, GJ

Marquez, R

Baldwin, JE

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Loughborough, Dept Chem, Leicester 2LE11 3TU, Leics, England

[3] Univ Dundee, Sch Life Sci, Dundee DD1 4HN, Scotland

来源：

TETRAHEDRON | 2004年 / 60卷 / 41期

基金：

英国工程与自然科学研究理事会;

关键词：

pyridovericin; pyridomacrolidin; Suzuki coupling; metal-halogen exchange;

D O I：

10.1016/j.tet.2004.07.035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the naturally occurring kinase inhibitor pyridovericin 1 is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2,4-dihydroxypyridine. Pyridovericin is a key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9307 / 9317

页数：11

共 31 条

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[12]

IHARA M, 1990, J CHEM SOC P1, V5, P1469

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