Total synthesis of pyridovericin

被引：20
作者：
Irlapati, NR
Adlington, RM
Conte, A
Pritchard, GJ
Marquez, R
Baldwin, JE
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[2] Univ Loughborough, Dept Chem, Leicester 2LE11 3TU, Leics, England
[3] Univ Dundee, Sch Life Sci, Dundee DD1 4HN, Scotland
来源：
TETRAHEDRON | 2004年 / 60卷 / 41期
基金：
英国工程与自然科学研究理事会;
关键词：
pyridovericin; pyridomacrolidin; Suzuki coupling; metal-halogen exchange;
D O I：
10.1016/j.tet.2004.07.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of the naturally occurring kinase inhibitor pyridovericin 1 is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2,4-dihydroxypyridine. Pyridovericin is a key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9307 / 9317
页数：11
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