Antibody-Mediated Rejection After Liver Transplant

被引：31

作者：

Lee, Michael ^{[1
]}

机构：

[1] Columbia Univ, Dept Pathol & Cell Biol, 630 West 168th St,VC14-238, New York, NY 10032 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 02期

关键词：

Liver; Antibody-mediated rejection; Transplant; DONOR-SPECIFIC ANTIBODIES; HISTOCOMPATIBILITY COMPLEX ANTIGENS; MASSIVE HEMORRHAGIC NECROSIS; BLOOD-GROUP BARRIERS; ALLOGRAFT-REJECTION; HLA ANTIBODIES; C4D DEPOSITS; INTRAGRAFT MICROENVIRONMENT; PERITUBULAR CAPILLARIES; HUMORAL REJECTION;

D O I：

10.1016/j.gtc.2017.01.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Antibody-mediated rejection (AMR) in liver transplants is a field in its infancy compared with its allograft cohorts of the kidney and lung. Acute AMR is diagnosed based on specific clinical and histopathologic criteria: serum donor specific antibodies, C4d staining, histopathologic findings on liver biopsy, and exclusion of other entities. In contrast, the histologic features of chronic AMR are not as specific and it is a more challenging diagnosis to make. Treatments of acute and chronic AMR include some combination of steroids, immune-modulating agents, intravenous immunoglobulin, plasmapheresis, and proteasome inhibitors.

引用

页码：297 / +

页数：14

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