Gd-meso-tetraphenylporphyrins: synthesis, encapsulation into liposomes and characterization of the resulting preparations

被引：1

作者：

Berezin, DB ^{[1
]}

Bonnett, R ^{[1
]}

de Madariaga, MA ^{[1
]}

Molina, S ^{[1
]}

Mora, M ^{[1
]}

Sagrista, ML ^{[1
]}

Valles, MA ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

PHOTOCHEMOTHERAPY: PHOTODYNAMIC THERAPY AND OTHER MODALITIES III, PROCEEDINGS OF | 1997年 / 3191卷

关键词：

gadolinium porphyrins; liposomes; incorporation efficiency; size;

D O I：

10.1117/12.297829

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

POPC, DPPC/DMPC and POPC/OOPS liposomes containing gadolinium(III) meso-tetraphenylporphyrin and gadolinium(III) meso-tetra(4-pyridyl)porphyrin have been prepared by different techniques, their porphyrin and lipid contents have been evaluated, and the size and stability of the liposomes have been determined. The results show the influence of the method of preparation on the amount of Gd-porphyrin incorporated, and that of the lipid composition on the incorporation efficiency and stability of the Gd(III) porphyrin trapped in the liposomes, as well as the presence of strong lipid to porphyrin association at least in the case of the DPPC/DMPC liposomes.

引用

页码：359 / 367

页数：9