Congenital microcephaly: A diagnostic challenge during Zika epidemics

被引：20

作者：

Alvarado-Socarras, Jorge L. ^{[1
,2
,3
]}

Idrovo, Alvaro J. ^{[4
]}

Contreras-Garcia, Gustavo A. ^{[5
]}

Rodriguez-Morales, Alfonso J. ^{[2
,3
,6
]}

Audcent, Tobey A. ^{[7
]}

Mogollon-Mendoza, Adriana C. ^{[8
,9
,10
]}

Paniz-Mondolfi, Alberto ^{[11
,12
]}

机构：

[1] Fdn Cardiovasc Colombia, Dept Pediat, Neonatal Unit, Floridablanca, Santander, Colombia

[2] OLFIS, Bucaramanga, Santander, Colombia

[3] Colombian Collaborat Network Zika RECOLZIKA, Pereira, Risaralda, Colombia

[4] Univ Ind Santander, Sch Med, Publ Hlth Dept, Bucaramanga, Colombia

[5] Univ Ind Santander, Res Grp Human Genet, Bucaramanga, Colombia

[6] Univ Tecnol Pereira, Publ Hlth & Infect Res Grp, Fac Hlth Sci, Pereira, Risaralda, Colombia

[7] Childrens Hosp Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

[8] Infect Dis Res Incubator, Caracas, Venezuela

[9] Zoonosis & Emerging Pathogens Reg Collaborat Netw, Caracas, Venezuela

[10] Univ Centroccidental Lisandro Alvarado, Coll Med, Hlth Sci Dept, Barquisimeto, Lara, Venezuela

[11] IDB Biomed Res Ctr, Dept Infect Dis & Trop Med, Infect Dis Pathol Lab IDB, Barquisimeto, Venezuela

[12] Inst Venezolano Los Seguros Sociales IVSS, Directorate Hlth, Caracas, Dtto Capital, Venezuela

来源：

TRAVEL MEDICINE AND INFECTIOUS DISEASE | 2018年 / 23卷

关键词：

Microcephaly; Zika; TORCH; Pregnancy infections; Latin America; VIRUS-INFECTION; MALFORMATION; AMERICA; BRAZIL;

D O I：

10.1016/j.tmaid.2018.02.002

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The multiple, wide and diverse etiologies of congenital microcephaly are complex and multifactorial. Recent advances in genetic testing have improved understanding of novel genetic causes of congenital microcephaly. The recent Zika virus (ZIKV) epidemic in Latin America has highlighted the need for a better understanding of the underlying pathological mechanisms of microcephaly including both infectious and non-infectious causes. The diagnostic approach to microcephaly needs to include potential infectious and genetic etiologies, as well as environmental in-utero exposures such as alcohol, toxins, and medications. Emerging genetic alterations linked to microcephaly include abnormal mitotic microtubule spindle structure and abnormal function of centrosomes. We discuss the diagnostic challenge of congenital microcephaly in the context of understanding the links with ZIKV emergence as a new etiological factor involved in this birth defect.

引用

页码：14 / 20

页数：7

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