Computer conformation analysis of TATA-box sequences in eukaryotic promoters

被引：0
|
作者：
Ponomarenko, MP [1 ]
Ponomarenko, YV
Kel', AE
Kolchanov, NA
Karas, H
Wingender, E
Sklenar, H
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia
[2] Gesell Biotechnol Forsch GmbH, D-38124 Braunschweig, Germany
[3] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany
来源：
MOLECULAR BIOLOGY | 1997年 / 31卷 / 04期
关键词：
TATA-box; computer analysis; B-DNA; transcription;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a method for revealing local conformation properties of binding sites for transcription factors, based on conformation indices of B-sheet DNA hexanucleotide duplexes and computer system SITEVIDEO. Analysis of sequences with TATA box has revealed the promoter regions with certain conformation indices of B-sheet DNA significantly changed as compared with arbitrary sequences: TATA-box DNA has a lower angle of helical twist, smaller distance between neighbor base pairs along the DNA helix axis, wider minor and narrower major DNA grooves.
引用
收藏
页码：623 / 630
页数：8
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