SYNTHESIS OF SOME NEW PYRIDAZINYLSPIROHETARYLINDOLES AND HETARYLPYRIDAZINE DERIVATIVES

被引：5

作者：

Gabr, Yassin ^{[1
]}

Abdel-Megid, Mohamed ^{[1
]}

Awas, Mohamed Abdel-Hamid ^{[1
]}

Abdel-Fatah, Naser Mohamed ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11757, Egypt

来源：

HETEROCYCLES | 2010年 / 81卷 / 02期

关键词：

INDOLE-3-CARBINOL;

D O I：

10.3987/COM-09-11845

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of 4-acetyl-5,6-diphenylpyridazine-3(2H)-one (1) with 1H-indol-2,3-dione afforded the biheterocyclic enone 2. Interaction of 2 with some bifunctional nitrogen nucleophiles and dimedone yielded some novel pyridazinyl spirohetarylindoles 3-6. The reaction of 3-chloropyridazine derivative 7 with some heterocyclic compounds having vicinal amino and cyano groups gave hetarylaminopyridazines 9 and 13. Treatment of acetylpyridazinone I with arylidenecyanoacetate and arylidenemalononitrile afforded pyridylpyridazines 16 and 19, respectively. The effect of some active methylene compounds and thioacetamide on biheterocyclic enone 22 was also studied.

引用

页码：395 / 406

页数：12

共 15 条

[1]

Abdel-Megid M., 2006, INT J CHEM, V16, P149

[2] A new route for the synthesis of substituted pyridazines [J].