Synthesis of chiral 3-substituted isoxazolidines.

被引：4
|
作者：
Farr, RN [1 ]
机构：
[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 3-4期
关键词：
D O I：
10.1016/S0040-4039(97)10523-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of chiral (>98% ee) 3-substituted isoxazolidines has been achieved. Glycidyl tosylate was utilized to establish the desired stereochemistry in a "double grignard" reaction sequence. Mesylate displacement followed by acid-catalyzed cyclization allows the parent isoxazolidines to be obtained. (C) 1997 Elsevier Science Ltd. All rights reserved.
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页码：195 / 196
页数：2
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