Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

被引：11

作者：

Mansour, Ahmad M. ^{[1
]}

Arevalo, J. Fernando ^{[2
,3
]}

Al Kahtani, Eman ^{[2
]}

Zegarra, Hernando ^{[4
]}

Abboud, Emad ^{[2
]}

Anand, Rajiv ^{[5
]}

Ahmadieh, Hamid ^{[6
]}

Sisk, Robert A. ^{[7
]}

Mirza, Salman ^{[8
]}

Tuncer, Samuray ^{[9
]}

Navea Tejerina, Amparo ^{[10
]}

Mataix, Jorge ^{[10
]}

Ascaso, Francisco J. ^{[11
]}

Pulido, Jose S. ^{[12
]}

Guthoff, Rainer ^{[13
]}

Goebel, Winfried ^{[14
]}

Roh, Young Jung ^{[15
]}

Banker, Alay S. ^{[16
]}

Gentile, Ronald C. ^{[17
]}

Alonso Martinez, Isabel ^{[18
]}

Morris, Rodney ^{[19
,20
]}

Panday, Neeraj ^{[21
]}

Min, Park Jung ^{[22
]}

Merce, Emilie ^{[23
]}

Lai, Timothy Y. Y. ^{[24
]}

Massoud, Vicky ^{[1
]}

Ghazi, Nicola G. ^{[2
]}

机构：

[1] Amer Univ Beirut, Rafic Hariri Univ Hosp, Dept Ophthalmol, Beirut, Lebanon

[2] King Khalid Eye Specialist Hosp, Vitreoretinal Div, Riyadh, Saudi Arabia

[3] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21287 USA

[4] Retina Associates Cleveland, Beachwood, OH 44122 USA

[5] Univ Texas SW Med Ctr Dallas, Texas Retina Associates, Dallas, TX 75231 USA

[6] Shahid Beheshti Univ Med Sci, Ophthalm Res Ctr, Labbafinejad Med Ctr, Tehran, Iran

[7] Cincinnati Eye Inst, Cincinnati, OH 45212 USA

[8] Birmingham Midland Eye Ctr, Birmingham B18 7QH, W Midlands, England

[9] Istanbul Univ, Dept Ophthalmol, Istanbul Fac Med, TR-34349 Istanbul, Turkey

[10] Fdn Oftalmol Mediterraneo, Valencia 46015, Spain

[11] Univ Zaragoza, Sch Med, Lozano Blesa Univ Clin Hosp, Dept Ophthalmol, Zaragoza 50001, Spain

[12] Mayo Clin, Rochester, MN 55902 USA

[13] Univ Eye Hosp Duesseldorf, D-40225 Dusseldorf, Germany

[14] Univ Wurzburg, Dept Ophthalmol, D-97080 Wurzburg, Germany

[15] Catholic Univ Korea, St Marys Hosp, Dept Ophthalmol, Seoul 137701, South Korea

[16] Bankers Retina Clin & Laser Ctr, Ahmadabad 380009, Gujarat, India

[17] New York Eye & Ear Infirm, Dept Ophthalmol, New York, NY 10014 USA

[18] Martinez Ctr, Madrid 28919, Spain

[19] Aravind Eye Hosp, Dept Retina & Vitreous, Coimbatore 641014, Tamil Nadu, India

[20] Postgrad Inst Ophthalmol, Coimbatore 641014, Tamil Nadu, India

[21] MM Joshi Eye Inst, Hubli 580021, Karnataka, India

[22] Maryknoll Med Ctr, Pusan 600730, South Korea

[23] CHU Dupuytren, Serv Ophtalmol, F-87042 Limoges, France

[24] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF OPHTHALMOLOGY | 2014年 / 2014卷

关键词：

TERM-FOLLOW-UP; PHOTODYNAMIC THERAPY; MEMBRANE; BEVACIZUMAB; SECONDARY; RANIBIZUMAB; PATIENT;

D O I：

10.1155/2014/210458

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0.001), 105.3 microns at 1 year (n = 10; P = 0.03), and 157.6 microns at 2 years (n = 7; P = 0.08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0.001), 2.8 lines (n = 20; P = 0.01) at 1 year, and 3.1 lines (n = 13; P = 0.049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.

引用

页数：8

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