The Evolving Landscape of Fungal Diagnostics, Current and Emerging Microbiological Approaches

被引:28
作者
Weiss, Zoe Freeman [1 ,2 ]
Leon, Armando [1 ]
Koo, Sophia [1 ]
机构
[1] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02115 USA
关键词
fungal diagnostics; mycoses; invasive candidiasis; invasive mold infections; invasive aspergillosis; mucormycosis; transplant; immunocompromised host; non-culture diagnostics; culture independent; INVASIVE PULMONARY ASPERGILLOSIS; DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; BRONCHOALVEOLAR LAVAGE FLUID; INTENSIVE-CARE-UNIT; GERM TUBE ANTIBODY; CANDIDA-ALBICANS; ANTIFUNGAL SUSCEPTIBILITY; PCR ASSAY; SPECIES IDENTIFICATION;
D O I
10.3390/jof7020127
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Invasive fungal infections are increasingly recognized in immunocompromised hosts. Current diagnostic techniques are limited by low sensitivity and prolonged turnaround times. We review emerging diagnostic technologies and platforms for diagnosing the clinically invasive disease caused by Candida, Aspergillus, and Mucorales.
引用
收藏
页码:1 / 27
页数:27
相关论文
共 148 条
  • [71] Elevated Levels of Interleukin 17A and Kynurenine in Candidemic Patients, Compared With Levels in Noncandidemic Patients in the Intensive Care Unit and Those in Healthy Controls
    Krause, Robert
    Zollner-Schwetz, Ines
    Salzer, Helmut J. F.
    Valentin, Thomas
    Rabensteiner, Jasmin
    Prueller, Florian
    Raggam, Reinhard
    Meinitzer, Andreas
    Prattes, Juergen
    Rinner, Beate
    Strohmaier, Heimo
    Quehenberger, Franz
    Strunk, Dirk
    Heidrich, Katharina
    Buzina, Walter
    Hoenig, Martin
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (03) : 445 - 451
  • [72] Use of recombinant antigens for the diagnosis of invasive candidiasis
    Lain, Ana
    Elguezabal, Natalia
    Amutio, Elena
    Fernandez de Larrinoa, Inigo
    Dolores Moragues, Maria
    Ponton, Jose
    [J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2008,
  • [73] Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis
    Lamoth, Frederic
    Clancy, Cornelius J.
    Tissot, Frederic
    Squires, Kevin
    Eggimann, Philippe
    Flueckiger, Ursula
    Siegemund, Martin
    Orasch, Christina
    Zimmerli, Stefan
    Calandra, Thierry
    Marchetti, Oscar
    Nguyen, Minh H.
    Bochud, Pierre-Yves
    [J]. OPEN FORUM INFECTIOUS DISEASES, 2020, 7 (03):
  • [74] Changes in the epidemiological landscape of invasive mould infections and disease
    Lass-Floerl, Cornelia
    Cuenca-Estrella, Manuel
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 : I5 - I11
  • [75] Galactomannan detection for invasive aspergillosis in immunocompromised patients
    Leeflang, Mariska M. G.
    Debets-Ossenkopp, Yvette J.
    Wang, Junfeng
    Visser, Caroline E.
    Scholten, Rob J. P. M.
    Hooft, Lotty
    Bijlmer, Henk A.
    Reitsma, Johannes B.
    Zhang, Mingming
    Bossuyt, Patrick M. M.
    Vandenbroucke-Grauls, Christina M.
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (12):
  • [76] Rapid Detection and Identification of Mucormycetes in Bronchoalveolar Lavage Samples from Immunocompromised Patients with Pulmonary Infiltrates by Use of High-Resolution Melt Analysis
    Lengerova, Martina
    Racil, Zdenek
    Hrncirova, Kristyna
    Kocmanova, Iva
    Volfova, Pavlina
    Ricna, Dita
    Bejdak, Petr
    Moulis, Mojmir
    Pavlovsky, Zdenek
    Weinbergerova, Barbora
    Toskova, Martina
    Mayer, Jiri
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (08) : 2824 - 2828
  • [77] Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: a 20-year autopsy study
    Lewis, Russell E.
    Cahyame-Zuniga, Lizebeth
    Leventakos, Konstantinos
    Chamilos, Georgios
    Ben-Ami, Ronen
    Tamboli, Pheroze
    Tarrand, Jeffrey
    Bodey, Gerald P.
    Luna, Mario
    Kontoyiannis, Dimitrios P.
    [J]. MYCOSES, 2013, 56 (06) : 638 - 645
  • [78] Identification by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and Antifungal Susceptibility Testing of Non-AspergillusMolds
    Li, Ying
    Wang, He
    Hou, Xin
    Huang, Jing-Jing
    Wang, Pei-Chang
    Xu, Ying-Chun
    [J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [79] Evaluation of the Bruker Biotyper Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry System for Identification of Aspergillus Species Directly from Growth on Solid Agar Media
    Li, Ying
    Wang, He
    Zhao, Yu-Pei
    Xu, Ying-Chun
    Hsueh, Po-Ren
    [J]. FRONTIERS IN MICROBIOLOGY, 2017, 8
  • [80] Whole-Genome Analysis of Exserohilum rostratum from an Outbreak of Fungal Meningitis and Other Infections
    Litvintseva, Anastasia P.
    Hurst, Steven
    Gade, Lalitha
    Frace, Michael A.
    Hilsabeck, Remy
    Schupp, James M.
    Gillece, John D.
    Roe, Chandler
    Smith, David
    Keim, Paul
    Lockhart, Shawn R.
    Changayi, Shankar
    Weil, M. Ryan
    MacCannell, Duncan R.
    Brandt, Mary E.
    Engelthaler, David M.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (09) : 3216 - 3222