Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer

被引：7
|
作者：
Li, Mingjie [1 ]
Wang, Qianyun [1 ]
Zheng, Qinqin [2 ]
Wu, Lin [1 ]
Zhao, Bin [1 ]
Wu, Yan'an [1 ]
机构：
[1] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Clin Lab, Xiamen 361102, Peoples R China
[2] Xiamen Univ, Dept Clin Lab, Fuzhou Hosp 2, Fuzhou 350007, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 13期
关键词：
breast cancer; KM plotter; P4HAs; prognosis; survival; SQUAMOUS-CELL CARCINOMA; MICROARRAY DATA; P4HA1; IDENTIFICATION; MUTATIONS; TOOL;
D O I：
10.2217/bmm-2020-0323
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: We aimed to evaluate the diagnostic and prognostic values of P4HAs in breast cancer (BC) patients. Materials & methods: Kaplan-Meier plotter was used to evaluate the prognostic values of P4HAs and correlations between their expression and clinical characteristics were assessed based on The Cancer Genome Atlas and the Human Protein Atlas. Results: The current study showed that P4HAs were highly expressed in BC patients with clinical stage I compared with nontumor control and elevated P4HAs were correlated with poor survival outcomes. Subtypes analysis revealed that P4HA1 and P4HA2 were most expressed in HER2+ subtypes patients. Univariate analysis displayed that elevated P4HA1 and P4HA3 correlated with unfavorable recurrence-free survival in mutated TP53 patients. Conclusion: This study indicated the diagnostic and prognostic roles of P4HAs members and broadened the biomarker fields of early diagnosis and prognostic monitoring of BC patients.
引用
收藏
页码：1085 / 1096
页数：12
相关论文
共 50 条
  • [21] Direct and continuous assay for prolyl 4-hydroxylase
    Gorres, Kelly L.
    Raines, Ronald T.
    ANALYTICAL BIOCHEMISTRY, 2009, 386 (02) : 181 - 185
  • [22] Collagen biosynthesis in gastric cancer: Immunohistochemical analysis of prolyl 4-hydroxylase
    Matsui, H
    Kubochi, K
    Okazaki, I
    Yoshino, K
    Ishibiki, K
    Kitajima, M
    JOURNAL OF SURGICAL ONCOLOGY, 1999, 70 (04) : 239 - 246
  • [23] mRNA levels for α-subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle
    Han, XY
    Wang, W
    Myllylä, R
    Virtanen, P
    Karpakka, J
    Takala, TES
    JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (01) : 90 - 96
  • [24] Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque
    Van den Diepstraten, C
    Papay, K
    Bolender, Z
    Brown, A
    Pickering, JG
    CIRCULATION, 2003, 108 (05) : 508 - 511
  • [25] Cloning, baculovirus expression and characterization of the type II alpha subunit of human prolyl 4-hydroxylase
    Annunen, P
    Helaakoski, T
    Veijola, J
    Pihlajaniemi, T
    Kivirikko, KI
    MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 3360 - 3360
  • [26] THE FUNCTION OF ASCORBATE WITH RESPECT TO PROLYL 4-HYDROXYLASE ACTIVITY
    NIETFELD, JJ
    KEMP, A
    BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 657 (01) : 159 - 167
  • [27] Selective and bioavailable inhibitors of collagen prolyl 4-hydroxylase
    Vasta, James D.
    Andersen, Kristen A.
    Raines, Ronald T.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [28] EFFECT OF HEPATIC INJURY ON PROLYL 3-HYDROXYLASE AND 4-HYDROXYLASE ACTIVITIES IN RAT-LIVER AND IMMUNOREACTIVE PROLYL 4-HYDROXYLASE CONCENTRATIONS IN LIVER AND SERUM
    RISTELI, J
    TUDERMAN, L
    TRYGGVASON, K
    KIVIRIKKO, KI
    BIOCHEMICAL JOURNAL, 1978, 170 (01) : 129 - 135
  • [29] MONOCLONAL-ANTIBODIES TO HUMAN PROLYL 4-HYDROXYLASE
    HOYHTYA, M
    MYLLYLA, R
    PIUVA, J
    KIVIRIKKO, KI
    TRYGGVASON, K
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 141 (03): : 477 - 482
  • [30] Bioavailable affinity label for collagen prolyl 4-hydroxylase
    Vasta, James D.
    Higgin, Joshua J.
    Kersteen, Elizabeth A.
    Raines, Ronald T.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (12) : 3597 - 3601
12345