Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer

被引：7

作者：

Li, Mingjie ^{[1
]}

Wang, Qianyun ^{[1
]}

Zheng, Qinqin ^{[2
]}

Wu, Lin ^{[1
]}

Zhao, Bin ^{[1
]}

Wu, Yan'an ^{[1
]}

机构：

[1] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Clin Lab, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Dept Clin Lab, Fuzhou Hosp 2, Fuzhou 350007, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 13期

关键词：

breast cancer; KM plotter; P4HAs; prognosis; survival; SQUAMOUS-CELL CARCINOMA; MICROARRAY DATA; P4HA1; IDENTIFICATION; MUTATIONS; TOOL;

D O I：

10.2217/bmm-2020-0323

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We aimed to evaluate the diagnostic and prognostic values of P4HAs in breast cancer (BC) patients. Materials & methods: Kaplan-Meier plotter was used to evaluate the prognostic values of P4HAs and correlations between their expression and clinical characteristics were assessed based on The Cancer Genome Atlas and the Human Protein Atlas. Results: The current study showed that P4HAs were highly expressed in BC patients with clinical stage I compared with nontumor control and elevated P4HAs were correlated with poor survival outcomes. Subtypes analysis revealed that P4HA1 and P4HA2 were most expressed in HER2+ subtypes patients. Univariate analysis displayed that elevated P4HA1 and P4HA3 correlated with unfavorable recurrence-free survival in mutated TP53 patients. Conclusion: This study indicated the diagnostic and prognostic roles of P4HAs members and broadened the biomarker fields of early diagnosis and prognostic monitoring of BC patients.

引用

页码：1085 / 1096

页数：12

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