Drug refractoriness of epileptiform activity in organotypic hippocampal slice cultures depends on the mode of provocation

被引：7

作者：

Wahab, Abdul ^{[1
]}

Albus, Klaus ^{[1
]}

Heinemann, Uwe ^{[1
,2
]}

机构：

[1] Charite, Inst Neurophysiol, D-10117 Berlin, Germany

[2] Charite, NeuroCure Ctr Excellence, D-10117 Berlin, Germany

来源：

EPILEPSY RESEARCH | 2010年 / 90卷 / 03期

关键词：

High-frequency stimulation; Hippocampal afterdischarge; In vitro model; Carbamazepine; Phenytoin; RAT HIPPOCAMPUS; SYNAPTIC CONNECTIONS; ORGANIZATION; DISCHARGES; GENERATION; EPILEPSY; TISSUE; FAIL;

D O I：

10.1016/j.eplepsyres.2010.06.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We previously reported that low Mg2+ or 4-aminopyridine induced seizure-like events in organotypic hippocampal slice cultures (OHSCs) were resistant to standard antiepileptic drugs (Albus et al., 2008). We now show that high-frequency electrical stimulation induced ictal-like afterdischarges in OHSCs are effectively suppressed by the standard antiepileptic drugs phenytoin and carbamazepine. Thus, a single OHSC can express both pharmacoresistant and pharmacosensitive epileptiform activities. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：304 / 308

页数：5

共 21 条

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