Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides

被引：14
|
作者：
Lu, Qianqian [1 ]
Guan, Haixing [1 ,2 ]
Wang, Yan-En [3 ]
Xiong, Dan [1 ]
Lin, Tingzhi [1 ]
Xue, Fei [2 ]
Mao, Jianyou [1 ]
机构：
[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Tech Inst Fluorochem TIF, Nanjing 211816, Peoples R China
[2] Nanjing Forestry Univ, Inst Mat Phys & Chem, Coll Sci, Nanjing 210037, Peoples R China
[3] Hebei Agr Univ, Coll Sci, Baoding 071000, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC SUZUKI-MIYAURA; ALPHA-BROMO ESTERS; ARYL BROMIDES; NEGISHI ARYLATIONS; NICKEL; HALIDES; MECHANISMS; LIGHT;
D O I：
10.1021/acs.joc.2c00707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95% ee). The mechanistic studies show that this reductive cross-coupling involves a radical pathway.
引用
收藏
页码：8048 / 8058
页数：11
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