A highly efficient enantioselective synthesis of 2-methyl chromans via four sequential palladium-catalyzed reactions

被引：14

作者：

Palucki, M ^{[1
]}

Yasuda, N ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 06期

关键词：

palladium; chroman; asymmetric;

D O I：

10.1016/j.tetlet.2004.12.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective synthesis of substituted 2-methyl chromans was accomplished in four steps using four sequential Pd-catalyzed reactions. A study of the key palladium-catalyzed regioselective aryl ether ring fort-nation of two different substrates was also carried out to better understand the factors which affect the selectivity of the reaction. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：987 / 990

页数：4

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