Recent advances in the applications of iPSC technology

被引：47

作者：

Wiegand, Connor ^{[1
]}

Banerjee, Ipsita ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15260 USA

[3] McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2019年 / 60卷

基金：

美国国家科学基金会;

关键词：

PLURIPOTENT STEM-CELLS; MODELING ALZHEIMERS-DISEASE; FUNCTIONAL HUMAN LIVER; INNER-EAR ORGANOIDS; IN-VIVO MODEL; CEREBRAL ORGANOIDS; RETINAL ORGANOIDS; SMALL-INTESTINE; GENERATION; DIFFERENTIATION;

D O I：

10.1016/j.copbio.2019.05.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pluripotent stems cells (PSCs) can be expanded indefinitely and differentiated into almost any organ-specific cell type. This has enabled the generation of disease relevant tissues from patients in scalable quantities. iPSC-derived organs and organoids are currently being evaluated both in regenerative therapy which are proceeding towards clinical trials, and for disease modeling, which are facilitating drug screening efforts for discovery of novel therapeutics. Here we will review the current efforts and advances in iPSC technology and its subsequent applications and provide a brief commentary on future outlook of this promising technology.

引用

页码：250 / 258

页数：9

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