Virus-specific T cell immune response in children and adolescents with chronic hepatitis B virus infection

被引:8
作者
Fischler, Bjorn [1 ]
Nystrom, Jessica
Bjornsdottir, Thora
Lindh, Gudrun
Hultgren, Catharina
机构
[1] Karolinska Univ Hosp, Dept Pediat, SE-14186 Huddinge, Sweden
[2] Karolinska Univ Hosp, Dept Clin Virol, Huddinge, Sweden
[3] Karolinska Univ Hosp, Dept Infect Dis, Huddinge, Sweden
关键词
genotype; T cell proliferation; cytokines; interferon treatment;
D O I
10.1097/MPG.0b013e31804a85ce
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: To study the hepatitis B-specific T cell-mediated immune response in chronically infected children and adolescents. Patients and Methods: In all, 36 HBsAg-positive patients, 2 to 19 years old. were included. There were 9 HBeAg-positive patients with normal levels of alanine aminotransferase (ALT) (group 1), 18 HBeAg-positive patients with elevated ALT (group 2), and 9 HBeAg-negative, anti-HBe-positive patients (group 3). Four patients in group 2 were treated with interferon during the study. In all patients, HBcAg-specific T cell proliferation and ALT levels were prospectively studied in repeated samples for a mean follow-up time of 1.6 years. The baseline HBV-DNA and plasma cytokine levels were determined, and genotypes were analyzed. Results: The percent of patients with at least 1 sample indicating T cell proliferation was 55% in group 1 and 89% in groups 2 and 3, respectively (P = 0.07 group 1 vs group 2, P = 0.013 group 1 vs the combined groups 2 and 3). Tendencies for positive correlations between the degree of T cell proliferation and ALT levels were noted in groups I and 3 and for negative correlations in HBeAg seroconverting patients of group 2. In patients with successful interferon treatment, a pattern of more vigorous T cell proliferation than in patients with spontaneous seroconversion was noted. Conclusions: A majority of patients showed signs of ongoing T cell proliferation. The continuation of the T cell-mediated immune response seems to be of importance in maintaining the HBeAg seroconversion over time.
引用
收藏
页码:75 / 83
页数:9
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