Pharmacogenetics of chemotherapy-induced nausea and vomiting

被引：22
作者：
Sugino, Shigekazu [1 ]
Janicki, Piotr K. [1 ]
机构：
[1] Penn State Coll Med, Penn State Hershey Med Ctr, Lab Perioperat Genom, Dept Anesthesiol, Hershey, PA 17033 USA
来源：
PHARMACOGENOMICS | 2015年 / 16卷 / 02期
关键词：
5-HT3; receptor; antiemetics; chemotherapy-induced nausea and vomiting; cytochrome P450; genetic variants; neurokinin; 1; pharmacogenetics; single nucleotide polymorphism; substance P; OPIOID RECEPTOR GENE; CATECHOL-O-METHYLTRANSFERASE; TACHYKININ NK1 RECEPTOR; HOUSE MUSK SHREW; CANCER-PATIENTS; POSTOPERATIVE NAUSEA; ANTIEMETIC EFFICACY; SUNCUS-MURINUS; MORPHINE CONSUMPTION; POLYMORPHISMS AFFECT;
D O I：
10.2217/pgs.14.168
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chemotherapy-induced nausea and vomiting (CINV) is associated with distressing adverse effects observed in patients during cytotoxic chemotherapy. One of the potential factors explaining suboptimal response to currently used antiemetics is variability in genes encoding enzymes and proteins that play a role in the action of antiemetic drugs. Pharmacogenomics studies of CINV are sparse and focus mainly on polymorphisms associated with serotonin receptor, drug metabolism and drug transport. Currently, the role of pharmacogenetics in mechanisms of CINV has not been fully unraveled, and it is premature to implement results of pharmacogenetic association studies of antiemetic drugs in clinical practice. More uniform studies, with genetic profiles and biomarkers relevant for the proposed target and transporter mechanisms, are needed.
引用
收藏
页码：149 / 160
页数：12
相关论文
共 86 条
[1]   Transmembrane signaling in the brain by serotonin, a key regulator of physiology and emotion [J].
Adayev, T ;
Ranasinghe, B ;
Banerjee, P .
BIOSCIENCE REPORTS, 2005, 25 (5-6) :363-385
[2]   Aversive and Reinforcing Opioid Effects A Pharmacogenomic Twin Study [J].
Angst, Martin S. ;
Lazzeroni, Laura C. ;
Phillips, Nicholas G. ;
Drover, David R. ;
Tingle, Martha ;
Ray, Amrita ;
Swan, Gary E. ;
Clark, J. David .
ANESTHESIOLOGY, 2012, 117 (01) :22-37
[3]  
[Anonymous], GENETIC VARIANTS ASS
[4]   Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists [J].
Babaoglu, MO ;
Bayar, B ;
Aynacioglu, AS ;
Kerb, R ;
Abali, H ;
Celik, I ;
Bozkurt, A .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 78 (06) :619-626
[5]   ROSTRAL HYPOTHALAMUS - A NEW NEUROANATOMICAL SITE OF NEUROCHEMICALLY-INDUCED EMESIS IN THE CAT [J].
BELESLIN, DB ;
REZVANI, AH ;
MYERS, RD .
BRAIN RESEARCH BULLETIN, 1987, 19 (02) :239-244
[6]  
Biesecker LG, 2014, NEW ENGL J MED, V370, P2418, DOI [10.1056/NEJMra1312543, 10.1056/NEJMc1408914]
[7]   The impact of pharmacogenomics on postoperative nausea and vomiting - Do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? [J].
Candiotti, KA ;
Birnbach, DJ ;
Lubarsky, DA ;
Nhuch, F ;
Kamat, A ;
Koch, WH ;
Nikoloff, M ;
Wu, L ;
Andrews, D .
ANESTHESIOLOGY, 2005, 102 (03) :543-549
[8]   Association of μ-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty [J].
Chou, W. -Y. ;
Yang, L. -C. ;
Lu, H. -F. ;
Ko, J. -Y. ;
Wang, C. -H. ;
Lin, S. -H. ;
Lee, T. -H. ;
Concejero, A. ;
Hsu, C. -J. .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2006, 50 (07) :787-792
[9]   Human opioid receptor A118G polymorphlism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy [J].
Chou, Wen-Ying ;
Wang, Cheng-Haung ;
Liu, Ping-Hsin ;
Liu, Chien-Cheng ;
Tseng, Chia-Chih ;
Jawan, Bruno .
ANESTHESIOLOGY, 2006, 105 (02) :334-337
[10]   5-HYDROXYTRYPTAMINE M-RECEPTOR ANTAGONISM TO PREVENT CISPLATIN-INDUCED EMESIS [J].
COSTALL, B ;
DOMENEY, AM ;
NAYLOR, RJ ;
TATTERSALL, FD .
NEUROPHARMACOLOGY, 1986, 25 (08) :959-961
123456789