One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach

被引：9

作者：

Slimani, Ichraf ^{[1
]}

Hamzaoui, Salwa ^{[1
]}

Mansour, Lamjed ^{[2
,3
]}

Harrath, Abdel Halim ^{[2
]}

Hamdi, Naceur ^{[1
]}

机构：

[1] Univ Carthage, Higher Inst Environm Sci & Technol, Res Lab Environm Sci & Technol LR16ES09, Hammam Lif, Tunisia

[2] King Saud Univ, Coll Sci, Zool Dept, POB 2455, Riyadh 11451, Saudi Arabia

[3] Univ Tunis El Manar, Fac Sci Tunis, Dept Biol, Lab Biodivers Parasitol & Ecol Aquat Syst, Tunis, Tunisia

来源：

JOURNAL OF KING SAUD UNIVERSITY SCIENCE | 2020年 / 32卷 / 01期

关键词：

Multicomponent reaction; 4-Hydroxycoumarin; Ethyl cyanoacetate; Antibacterial and acetylcholinesterase inhibition activities; ANTIMICROBIAL ACTIVITY; DERIVATIVES; DISCOVERY; APOPTOSIS; ALKALOIDS;

D O I：

10.1016/j.jksus.2019.11.023

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Quantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux. The optimization details of the developed novel protocol are recorded. The structure of newly synthesized compounds have been characterized by spectroscopic data (elemental analysis, IR and H-1 NMR spectroscopic studied). Antimicrobial properties of the novel coumarins derivatives 3 are investigated. The acetylcholinesterase inhibition activity (AChEI) was tested for all compounds, and the 3b shows the highest AChEI activity with 48.25% of inhibition. (C) 2019 Published by Elsevier B.V. on behalf of King Saud University.

引用

页码：1212 / 1217

页数：6

共 22 条

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