Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

被引：79
作者：
Arnold, LD
Calderwood, DJ
Dixon, RW
Johnston, DN
Kamens, JS
Munschauer, R
Rafferty, P
Ratnofsky, SE
机构：
[1] BASF Pharma, Nottingham NG1 1GF, England
[2] BASF Biores Corp, Worcester, MA 01605 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(00)00441-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：2167 / 2170
页数：4
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